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New arrival,MDA-19 CAS 1048973-47-2
Information:
MDA-19
CAS:1048973-47-2
Details
MDA 19 is a potent and selective agonist of human cannabinoid receptor 2 (CB2), with a Ki of 43.3 nM. MDA 19 has antiallodynic effects in a rat model of neuropathic pain and does not affect rat locomotor activit.


In Vitro,MDA19 displayed 4-fold-higher affinity at the human CB(2) than at the human CB1 receptor (K(i) = 43.3 +/- 10.3 vs 162.4 +/- 7.6 nM) and nearly 70-fold-higher affinity at the rat CB2 than at the rat CB1 receptor (K(i) = 16.3 +/- 2.1 vs 1130 +/- 574 nM). In guanosine triphosphate (GTP)gamma[(35)S] functional assays, MDA19 behaved as an agonist at the human CB1 and CB2 receptors and at the rat CB1 receptor but as an inverse agonist at the rat CB2 receptor. In 3',5'-cyclic adenosine monophosphate (cAMP) assays, MDA19 behaved as an agonist at the rat CB1 receptor and exhibited no functional activity at the rat CB(2) receptor. In extracellular signal-regulated kinases 1 and 2 activation assays.

We has not independently confirmed the accuracy of these methods. They are for reference only.


In Vivo,MDA19 behaved as an agonist at the rat CB2 receptor. MDA19 attenuated tactile allodynia produced by spinal nerve ligation or paclitaxel in a dose-related manner in rats and CB2(+/+) mice but not in CB2(-/-) mice, indicating that CB2 receptors mediated the effects of MDA19. MDA19 did not affect rat locomotor activity.

We has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular weight : 349.43
Formula : C₂₁H₂₃N₃O₂
CAS number : 1048973-47-2
SMILES : O=C(N/N=C1C(N(CCCCCC)C2=C\1C=CC=C2)=O)C3=CC=CC=C3
Transport conditions : Room temperature in continental US; may vary elsewhere.

Storage method
Powder -20°C 3 years; 4°C 2 years
In solvent -80°C 6 months; -20°C 1 month

Solubility data
In Vitro:
DMSO: 14.29 mg/mL (40.90 mM; Need ultrasonic)

Prepare stock solution
Concentration solvent volume mass 1 mg 5 mg 10 mg
1 mM 2.8618 mL 14.3090 mL 28.6180 mL
5 mM 0.5724 mL 2.8618 mL 5.7236 mL
10 mM 0.2862 mL 1.4309 mL 2.8618 mL

Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in aliquots to avoid product failure caused by repeated freezing and thawing.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use within 6 months, and when stored at -20°C, please use within 1 month.

In Vivo:
Please choose an appropriate dissolution plan according to your experimental animals and the way of administration. For the following dissolution schemes, please first prepare a clear stock solution according to the In Vitro method, and then add co-solvents in sequence:
In order to ensure the reliability of the experimental results, the clarified stock solution can be properly stored according to the storage conditions; the working solution of the in vivo experiment is recommended to be used now and used on the same day;
The fraction refers to the volume ratio of the solvent in your final solution; if precipitation or precipitation occurs during the preparation process, it can be heated and/or ultrasonic to help dissolve

1.
Please add each solvent in order: 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: 1.43 mg/mL (4.09 mM); Suspended solution; Need ultrasonic
This program can obtain a uniform suspension of 1.43 mg/mL (4.09 mM), which can be used for oral and intraperitoneal injection.
Taking 1 mL of working solution as an example, take 100 μL of 14.3 mg/mL clarified DMSO stock solution and add it to 900 μL of 20% SBE-β-CD saline solution and mix well.

2.
Please add each solvent in order: 10% DMSO 90% corn oil
Solubility: ≥ 1.43 mg/mL (4.09 mM); Clear solution
This program can obtain a clear solution ≥ 1.43 mg/mL (4.09 mM, saturation unknown). This program is not suitable for experiments with an experimental period of more than half a month.
Take 1 mL working solution as an example, take 100 μL 14.3 mg/mL clarified DMSO stock solution and add it to 900 μL corn oil and mix well.
 

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